If antivirus software is running on your Microsoft System Center 2012 Virtual Machine Manager server (VMM 2012 or VMM 2012 R2) or the managed hosts, antivirus exclusions should be set. This new Knowledge Base article below describes the antivirus exclusions as they pertain to the SCVMM 2012 server itself and to the hosts that are managed by SCVMM.
KB3119208 - Recommended antivirus exclusions for System Center Virtual Machine Manager and managed hosts (https://support.microsoft.com/en-us/kb/3119208)
J.C. Hornbeck| Solution Asset PM | Microsoft GBS Management and Security Division
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ConfigMgr 2012 R2